Post-Doctoral Fellow In Vascular Mechanobiology H/F - 42

Joining Mines Saint-Étienne means committing to an institution where science and innovation build a more sustainable future. It is a school of excellence where everyone has the opportunity to unlock their full potential and contribute to tackling the challenges of tomorrow.

Ranked among the top engineering schools in France and recognized worldwide, our school, a member of the Institut Mines-Télécom, educates the talents of tomorrow while actively addressing major industrial, digital, and environmental challenges. By joining us, you become part of a community of 500 members of staff, 2,500 students and take part in an ambitious project: combining academic excellence, cutting-edge research, and positive societal impact.

The Institut Mines-Télécom brings together France's leading Grandes Ecoles to tackle major industrial, digital, energy, and environmental challenges. With its eight public Grandes Écoles and two affiliated Graduate Schools, it is the leading public institute dedicated to engineers and managers. Together, we imagine and build a sustainable future by educating the leaders who will shape tomorrow's transitions.What we expect from you

As Post-Doctoral Fellow in Vascular Mechanobiology, you will join the Biomechanics and Mechanobiology group of Professor Stéphane Avril within the SAINBIOSE research unit (Inserm U1059), based at the Centre Ingénierie et Santé in Saint-Étienne. You will contribute to the ERC Advanced Grant project JuvenTwin, focused on Multiscale mechanobiological synergies in vascular homeostasis, ageing and rejuvenation, and to an ANR-funded project.

The CIS (Centre Ingénierie et Santé) brings together around 70 people, including 18 professors in engineering, biomechanics and healthcare engineering. It has established itself as a leader in research on biomechanics and biomedical engineering, combining experimental, computational and translational approaches in collaboration with hospitals and industry.

Your mission will be to :

- Map mechanical stimuli around vascular smooth muscle cells in collagen hydrogels, including strain gradients, strains and stresses, and correlate them to specific local phenotypic parameters.
- Develop real-time imaging approaches for in situ characterization of cell-matrix mechanical interactions.
- Use the experimental data to develop a machine learning model of the mechanical interactions between the cell and its environment.
- Contribute to collaborative research activities within the ERC JuvenTwin project and the ANR project on vascular mechanobiology.

Your work will help establish multiscale digital twins of ageing effects on vascular mechanobiology and will contribute to the identification of rejuvenation treatments for vascular tissues.